Intended Use: MOTS-c is designed for Research Purposes only.
Storage: Store the vial in a cool, dry place away from direct sunlight. Once reconstituted, keep refrigerated at 2-8°C.
Solubility: Reconstitute with bacteriostatic water for best results.
Shelf Life: The lyophilized form has a shelf life of 24 months when properly stored. Once reconstituted, refrigerate and use within 4-6 weeks.
Handling: Ensure sterile techniques are used to maintain the product’s integrity during research.
Observations from phase 2 and phase 3 clinical trials.
Weight reduction: In the phase 2 trial, cagrilintide 4.5 mg weekly produced approximately 10.8% body weight loss over 26 weeks versus 3.0% with placebo.
Combination therapy: When combined with semaglutide 2.4 mg (CagriSema), phase 3 REDEFINE trials showed approximately 20% weight loss at 68 weeks, exceeding results with either agent alone.
Dose‑dependent efficacy: Higher doses (2.4–4.5 mg) demonstrate greater weight loss than lower doses (0.3–1.2 mg).
Side effects: Primarily gastrointestinal—nausea, vomiting, diarrhea, and constipation—which are generally mild‑to‑moderate and transient. Gradual titration helps minimize these effects.
Injection‑site reactions: Occasional mild redness or irritation at subcutaneous injection sites.
Cagrilintide is an acylated, long‑acting analogue of amylin—a hormone co‑secreted with insulin from pancreatic beta cells. Native amylin promotes satiation, slows gastric emptying, and inhibits postprandial glucagon secretion. By acting on central amylin receptors (particularly in the area postrema and hindbrain), cagrilintide reduces appetite and energy intake.
Cagrilintide is a long‑acting acylated analogue of the pancreatic hormone amylin, designed for once‑weekly subcutaneous administration. It activates central amylin receptors to promote satiety, slow gastric emptying, and reduce food intake. In phase 2 and phase 3 trials, cagrilintide produced dose‑dependent weight loss with a predominantly gastrointestinal side‑effect profile.
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